Ximing XU

Big Data Center for Children's Medical Care

Children's Hospital of Chongqing Medical University

Email: ximing@hospital.cqmu.edu.cn

About Me

I am an associate professor and principal statistician at the Big Data Center for Children's Medical Care, Children's Hospital of Chongqing Medical University. Previously, I was an assistant professor at Nankai University. I received my Ph.D. in Statistics from the University of Toronto in 2012, and I was fortunate to have Prof. Nancy Reid as my advisor for my thesis. After graduation I became a postdoctoral fellow at Dalhousie University (working with Prof. Chris Field). Before going to UofT, I got my bachelor's degree from Nankai University and master's degree from University of Ottawa under the supervision of Prof. David Sankoff.

At PediatriXlab, our primary focus is to address data-driven challenges in pediatrics through the integration of data analytics and artificial intelligence. The "X" in our name symbolizes both an interdisciplinary approach and a quest into the unknown.

Publications

• • Wei, Q., Dong, W.,..., Xu, X. , Li, T. (2024).Early identification of autism spectrum disorder based on machine learning with eye-tracking data. Journal of Affective Disorders. 358, 326-334.
  • Zhu, Z., Liu, L., Du, M., Ye, M., Xu, X. , Xu, Y. (2024). Pediatric Sedation Assessment and Management System (PSAMS) for Pediatric Sedation in China: Development and Implementation Report. JMIR Medical Informatics. 12(1), e53427.
  • Wei, Q., Xiao, Y., Yang, T., ..., Xu, X. , Li, T. (2024). Predicting Autism Spectrum Disorder Using Maternal Risk Factors: A Multi-Center Machine Learning Study. Psychiatry Research, 334: 115789.
  • Wei, Q., Yao, Z., Cui, Y., Wei, B., Jin, Z., Xu, X. . (2024). Evaluation of ChatGPT-generated medical responses: A systematic review and meta-analysis. Journal of Biomedical Informatics, 151:104620.
  • Xu, L., Reid, N., Xu, X. (2023). A note on information bias and efficiency of composite likelihood. Statistica Sinica, 2023, 34: 523-526.
  • Xu, L., Kong, D., Wang, L., Gu, H., Kenney, T., Xu, X. (2023). Proportional stochastic generalized Lotka-Volterra model with an application to learning microbial community structures. Applied Mathematics and Computation, 448: 127932.
  • Wei, Q., Wang, Y., Yao, Z., Cui, Y., Wei, B., Li, T., Xu, X. (2023). Evaluation of ChatGPT’s performance in providing treatment recommendations for pediatric diseases. Pediatric Discovery, 1(3), e42.
  • Hu, S., Xu, X. , Li, C., et al. (2023). Long-term exposure to ambient ozone at workplace is positively and non-linearly associated with incident hypertension and blood pressure: longitudinal evidence from the Beijing-Tianjin-Hebei medical examination cohort. BMC Public Health, 23: 2011.(PhD student Songhua Hu is the first author)
  • Wei, Q., Cui, Y., Wei, B., Cheng, Q., Xu, X. (2023). Evaluating the performance of ChatGPT in differential diagnosis of neurodevelopmental disorders: A pediatricians-machine comparison. Psychiatry Research, 327: 115351.
  • Wei, Q., Xu, XL.,  Xu, X. , Cheng, Q. (2023). Early identification of autism spectrum disorder by multi-instrument fusion: A clinically applicable machine learning approach. Psychiatry Research, 320: 115050.
  • Xiao, L., Xu, X. , et al. (2023). Low total cholesterol predicts early death in children with hemophagocytic lymphohistiocytosis. Frontiers in Pediatrics, 10: 1006817.
  • Wei, Q., Cao, H., Shi, Y., Xu, X. , Li, T. (2022). Machine learning based on eye-tracking data to identify Autism Spectrum Disorder: A systematic review and meta-analysis. Journal of Biomedical Informatics, 137: 104254.
  • Luo, Y., Tan, L., et al. (2022). Characteristics of wild bird resistomes and dissemination of antibiotic resistance genes in interconnected bird-habitat systems revealed by similarity of bla_TEM polymorphic sequences. Environmental Science & Technology, 56 (21), 15084-15095.
  • Li, J., An, X., Xu, X. , et al. (2022). Type O blood, the MCHC, and the reticulocyte count impact the early recurrence of primary warm-antibody autoimmune hemolytic anemia in children: a retrospective cohort analysis. Frontiers in Pediatrics, 10: 881064.
  • Li, Y., Xu, X. , Guo, Z., et al. (2022). Neonatal Streptococcus pneumoniae infection induces long-lasting dysbiosis of the gut microbiota in a mouse model. Frontiers in Microbiology, 13: 961684.
  • He, J., Hu, S., Xu, X. , et al. (2022).  Association of long-term exposure to PM2. 5 in workplace with fasting plasma glucose among asymptomatic adults: A multicenter study in North China. Environment International, 166: 107353. (PhD student Songhua Hu is the co-first author)
  • Aeberhard, W., Cantoni, E., Field, C., Künsch, H., Mills-Flemming, J., and Xu, X. (2021). Robust estimation for discrete-time state space models. Scandinavian Journal of Statistics, 48, 1127-1147. (Authors are alphabetically ordered)
  • Ma, J., Xu, XL., Li, M., Zhang, Y.…, Xu, X. , Wang, Y. (2021). Predictive models of aging of the human eye based on ocular anterior segment morphology. Journal of Biomedical Informatics, 120: 103855. (PhD student Xueli Xu is the co-first author)
  • Zeng, Q., Yang, Z., Wang, F., Li, D., .…, Xu, X. , Dai, W. (2021). Association between metabolic status and gut microbiome in obese populations. Microbial Genomics, 7：000639.
  • Xu, X. and Xu, L. (2020). Existence and asymptotic behaviour of positive solutions to a stochastic multispecies Holling type II model. Stat, 9: e266.
  • Xu, XL., Xie, Z., Yang, Z., Li, D. and Xu, X. (2020). A t-SNE based classification approach to compositional microbiome data. Frontiers in Genetics, 11:620143. (PhD student Xueli Xu is the first author)
  • Li, H., et al. (2020). The prolonged disruption of a single-course amoxicillin on mice gut microbiota and resistome, and recovery by inulin. Environmental Pollution, 265: 114651.
  • Yang, J., Li, D., Yang, Z. …, Xu, X. , et al. (2020). Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families. Gut Microbes, 11, 918-929. (PhD student Zhenyu Yang is the co-first author).
  • Dong, G., Zhang, J., Yang, Z. …, Xu, X. , et al. (2020). The association of gut microbiota with idiopathic central precocious puberty in girls. Frontiers in Endocrinology, 10: 941.(PhD student Zhenyu Yang is the co-first author).
  • Zhou, P., et al. (2020). Perinatal antibiotic exposure affects the transmission between maternal and neonatal microbiota and is associated with early-onset sepsis. Msphere, 5: e00984-19.
  • Huang, C. …, Xu, X. , et. al. (2019). Distinct gut microbiota composition and functional category in children with cerebral palsy and epilepsy. Frontiers in Pediatrics, 7: 394.
  • Dai, W., et al. (2019). An integrated respiratory microbial gene catalogue to better understand the microbial aetiology of Mycoplasma pneumoniae pneumonia. GigaScience, 8: giz093.
  • Li, D., et al. (2019). Intestinal Bacteroides sp. imbalance associated with the occurrence of childhood undernutrition in China. Frontiers in Microbiology, 10:2635.
  • Zeng, Q., et al. (2019). Discrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities. Scientific Reports, 9: 13424.
  • Xu, X. , Cantoni, E., Mills-Flemming, J. and Field, C. (2015). Robust state space models for estimating fish stock maturities. Canadian Journal of Statistics, 43, 133-150.
  • Xu, X. , Dunn, K. and Field, C. (2015). A robust ANOVA approach to estimating a phylogeny from multiple genes. Molecular Biology and Evolution, 32, 2186-2194.
  • Xu, X. and Reid, N. (2011). On the robustness of maximum composite likelihood estimate. Journal of Statistical Planning and Inference, 141, 3047-3954.
  • Costa, V., Dantas, S., Sankoff, D. and Xu, X. (2012). Gene clusters as intersections of powers of paths. Journal of the Brazilian Computer Society, 18, 129-136.
  • Xu, X. and Sankoff, D. (2008). Tests for gene clusters satisfying the generalized adjacency criterion. Lecture Notes in Computer Science, 5167, 152-160. (This paper was chosen as the first best full paper of the 3rd Brazilian Symposium on Bioinformatics)
  • 王言覃 , 张拔群 , 李秋 ,  徐铣明 (2023). 真实世界研究在儿科人群中的应用现状与挑战. 中华儿科杂志, 61(04): 377-380.
  • 高洁, 徐雪丽, 徐铣明 , 韦秋宏, 张站站, 程茜 (2021). 真实世界不同出生体重早产儿体格生长规律的研究. 中华儿科杂志, 59(8):665-671.
  • 魏凤英, 王金杰, 徐铣明 , 高建召, 王博灵, 马驰宇, 彭志行, 靳祯, 黄森忠 (2020). 全球新型冠状病毒肺炎疫情发展趋势预测. 疾病监测, 6: 467-472.
  • 黄森忠, 魏凤英 , 彭志行, 靳祯, 王金杰, 徐铣明 , 张新岩, 徐建国 (2020). 常态化防控下新型冠状病毒肺炎新发疫情研判方法. 疾病监测, 8: 679-686.
  • 万燕南, 隋雅楠, 徐铣明 , 张站站, 钟元峰, 程茜 (2019). 出生体重不一致双胎0～4岁体格生长状况研究. 中国实用儿科杂志, 34: 689-693.

Decision Aids

• 1. A two-stage decision model for early Identification of autism Spectrum disorder by combining behavioral and developmental scales

• 2. Modified PIRO: A Prognostic Scale for Children with CAP

People

Current Students

Mengwei Ding, MSc in Applied Statistics (2022-present)

Yanqin Wang, MD in Pediatrics （2021-present, co-supervised with Prof. Qiu Li）

Qiuhong Wei, MD in Pediatrics （2021-2024, co-supervised with Prof. Tingyu Li）

Former Students

Libai Xu (PhD student, graduated: 2020 ), Assistant Professor at Soochow University (苏州大学)

Xueli Xu (PhD student, graduated: 2021), Postdoctoral fellow at Guangzhou Institute of Biomedicine and Health (GIBH), Chinese Academy of Sciences

Siyu Chen (Master student, graduated: 2019), PhD student at the Nuffield Department of Medicine, University of Oxford.

Wanfeng Liang (PhD student at Nankai), now a fifth-year PhD student in Statistics at Nankai University

Zhenyu Yang (PhD student at Nankai), now a fourth-year PhD student in Statistics at Nankai University

Songhua Hu (PhD student at Nankai), now a third-year PhD student in Statistics at Nankai University

Ying Cui (Undergraduate RA, graduated: 2017 ), PhD student in the Department of Biostatistics and Bioinformatics at Emory University

Yongkai Chen (Undergraduate RA, graduated: 2019 ), PhD student in the Department of Statistics at University of Georgia

Yu Lu (Undergraduate RA, graduated: 2020 ), PhD student in Biostatistics at Johns Hopkins University

Zhongming Xie (Undergraduate RA, graduated: 2022), M.S. in Biostatistics at University of California, Berkeley

If you are interested in what I am doing and looking for a research internship, please feel free to contact me at ximing@hospital.cqmu.edu.cn.

Consulting

At the Children’s Hospital of Chongqing Medical University (CHCMU), I provide consulting services to clinical researchers on study design and statistical methodology, as well as R programming workshops. Prior to joining CHCMU, I founded the Nankai Data Analytics and Consulting Service (NKDACS)

Miscellaneous

• Translated the wonderful story ( Statistics and the Ontario Lottery Retailer Scandal ) by Prof. Jeffrey Rosenthal into Chinese .
• MIMIC数据库简介&下载与安装教程 ( Website )